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In preclinical models, BPC-157 is investigated for its activity across several interconnected signaling cascades, including the VEGFR2/eNOS angiogenic axis, the FAK-paxillin pathway in tendon fibroblasts, and ERK1/2-mediated transcription factor activation

Over time, the ongoing NETosis and chronic inflammation lead to irreversible lung damage and a decline in pulmonary function

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